Annual Report for the International Federation of Red Cross and Red Crescent Societies (IFRC) in 2021. This report is presented in two parts: The IFRC 2021 report details how the IFRC supported National Societies to respond to the most pressing humanitarian challenges of 2021. It is organized by the IFRC’s strategic outlook, strategic priorities and enablers. A Federation-wide perspective highlightssome of the excellent work that was undertaken by the entire IFRC network in 2021. This includes the international work of member National Societies and the IFRC network’s reference centres. The achievements outlined in this report would not have been possible without the contribution of unearmarked funding from our partners. We thank them, all our National Societies and our nearly 15 million volunteers for their continuing and inspiring support to the most vulnerable communities around the world.